The Importance of Training in Microsurgical and Experimental Techniques in Small Rodents Introduction Advances in biomedical research and translational medicine increasingly depend on precise, reproducible, and ethically conducted experiments. Among these, microsurgical and experimental techniques in small rodents – particularly rats and mice – are central to developing and validating new therapies. High-quality training is essential to ensure scientific reliability and animal welfare. The René Remie Surgical Skills Centre (RRSSC) is a leading institution dedicated to equipping researchers and clinicians with these critical competencies. Why Microsurgical Training Matters Microsurgery involves operating on very small anatomical structures such as blood vessels, lymphatic vessels and nerves, often under high magnification. In rodent models, these procedures are foundational for: Without proper training, these procedures can lead to inconsistent results, increased animal use, and compromised data quality. Structured training ensures that participants develop the fine motor skills, hand-eye coordination, and procedural confidence required for success. The Role of Experimental Rodent Models Rats and mice are indispensable in preclinical research due to their genetic similarity to humans, well-characterised biology, and adaptability to experimental manipulation. Techniques commonly performed include: Mastering these techniques requires not only technical skill but also a deep understanding of good surgical practice, anaesthesia, analgesia, perioperative care, and experimental design. RRSSC training programmes integrate all of these elements into a cohesive learning experience. RRSSC: A Comprehensive Training Environment RRSSC provides a unique, hands-on training environment that bridges the gap between theory and practice. Its programmes are designed for researchers, PhD candidates, technicians, and clinicians who require practical expertise in rodent surgery and experimental techniques. Key Features of RRSSC Training: Ethical and Scientific Responsibility Proper training is not only a technical necessity but also an ethical obligation. Poorly performed procedures can lead to unnecessary animal suffering and unreliable results, ultimately undermining scientific progress. RRSSC …
Guru Prasad Padmasola
I had the pleasure of attending the 5-day Module C course at the René Remie Surgical Skills Centre (RRSSC) in Almere, the Netherlands, from October 6 to 10, 2025, with a special focus on radiotelemetry in mice. The instructors, René Remie and Irene Cuesta, were exceptionally kind, knowledgeable, and supportive throughout the course. René, with his vast experience, not only explained the theoretical aspects but also enriched the sessions with fascinating stories from his own research, the history of techniques, and insights about the scientists who developed them. This made the theory classes highly engaging and memorable. Irene also led some theory and practical sessions, providing clear guidance and hands-on support. During the practical sessions, both René and Irene supervised every step of the procedures, ensuring I gained confidence and skill. I learned carotid artery catheterisation, implantation of the Stellar telemetry device, and ECG lead suturing. My suturing technique improved significantly, and I gained valuable knowledge about instrument handling, asepsis, anaesthesia, and rodent surgical care. René provided continuous feedback, helping me refine my techniques in ways that enhance the animals’ recovery and ensure procedural success. Even after the course, they were happy to patiently answer all my questions, making me feel comfortable and well-prepared to implement everything back in my lab. The course also had a warm, personal touch—lunches felt like family sessions, adding to a welcoming and collaborative atmosphere. Overall, the RRSSC Module C course exceeded my expectations. It provided not only technical skills and theoretical knowledge but also inspiration, guidance, and the confidence to apply these techniques in my own research. I highly recommend this course to anyone looking to deepen their expertise in rodent-based surgical research.
ADInstruments & RRSSC co-organise a 3-day KAHA radiotelemetry course on July 6-8, 2026
Radiotelemetry is a powerful technique that requires implanting a telemetry device. We will take you through the entire surgical procedure, ensuring you can use the technique in your own laboratory. We are pleased to announce that ADInstruments, in collaboration with RRSSC, will jointly host a comprehensive three-day training course focused on radiotelemetry techniques. Scheduled to take place from July 6th to July 8, 2026, this event aims to provide participants with in-depth knowledge and practical skills essential for implementing telemetry in research settings. Throughout the course, attendees will gain valuable insights into surgical procedures for implanting telemetry devices, with an emphasis on best practices to ensure animal welfare and data accuracy. The programme will also cover critical aspects of surgical preparation, including appropriate suture materials, instrumentation, anaesthesia, and aseptic technique. Participants will have the opportunity to engage with experienced professionals and enhance their technical expertise in a collaborative environment. The course will be held in Almere, the Netherlands, offering an excellent setting for professional development and networking within the scientific community. We look forward to welcoming researchers and practitioners committed to advancing their skills in radiotelemetry applications.
Poland
This June 2025 training was fantastic! It covered not only the basics of Good Surgical Practice, suturing, anaesthesia, and perioperative care of laboratory animals, but also a practical approach to our own techniques and problems. The discussions with René and Irene gave me a better understanding of animals’ reactions and physiology during surgery. Together, we refined my procedures, which will consequently improve the welfare of the animals.
Mathias, Denmark
“I recently completed the Glucose Clamp Course at the RRSSC and can highly recommend it. Although I began with limited experience in this specific technique, the comprehensive 7-day program thoroughly prepared me to independently perform the associated surgical procedures. In addition to its specialised focus on carotid and jugular vein catheterisation, the course provides an excellent foundation in fundamental surgical practices, including aseptic techniques and anaesthesia.”
Mikhail, Karolinska Institutet, Sweden
Absolutely the best course to develop skills for microsurgery. The best combination of theoretical and practical skills. My aim was to increase my techniques in end-to-slide anastomosis for rat kidney transplantation. I got a personal plan and course design including private presentation and advice for many small tricks. I highly recommend the course to beginners and advanced users of microsurgical techniques! Hartelijk dank René and Muchas gracias Irene!!!
Vasiliki, Italy
I participated in the December 2023, 5-day Module B, Microsurgical and Experimental Techniques course intending to learn how to perform one of the most difficult surgeries in small rodents. As a total beginner, I had very low expectations for my performance in this training. However, in only 5 days I gained both theoretical and practical knowledge for microsurgeries, knots, anesthesia, and anatomy, which in my mind I expected to take months or even a whole year to obtain. I actually managed to perform the whole surgery! René and Irene are top on what they do and most importantly, they respect the animals and their welfare, which is what they try to teach you throughout the course. They are very helpful, follow you on every step, and give you all the required knowledge to successfully perform your surgery from the detailed protocol to the specific instruments that you are going to need. The environment was very friendly and the whole experience was amazing! Thank you René and Irene for everything!!
E. Muñoz, The Netherlands
I attended a Module B course in 2023. It was a great pleasure to receive first-hand lectures and guidelines from René Remie, the renowned microsurgery expert. I learned more than expected about all my techniques of interest. In addition to the knowledge, I greatly appreciate the generosity of René and Irene in sharing their vast experience, their library, the answer to every question, their scientific opinion, and, of course, the opportunity to be personally trained by both. If possible, I recommend following the five-day course because, although time is never enough, one week is suitable for correcting mistakes, practising, checking the best surgical tools, and discussing the different surgical techniques. Thank you very much for a fruitful week!
Stefen, DVM, Switzerland
I am writing to express my deepest gratitude for the outstanding theoretical and practical course you and Irene gave in Bellinzona, where I have seen, practised and learned new procedures and skills, taught with a dedication that has left an indelible impact on my knowledge and I feel compelled to convey my heartfelt thanks. I am grateful not only for the successful outcome of the microsurgery course but also for the manner in which you and Irene conducted yourselves. Your dedication to your craft and the welfare of your ‘’patients’’ is truly admirable and presented in a collegial atmosphere. To conclude 😊… YOU ROCK!
Basel Switzerland
I completed the animal surgery course at the RRSSC and I must say it exceeded my expectations. The course content was comprehensive, covering a wide range of surgical techniques and procedures. The instructors were experienced professionals who provided clear explanations and hands-on demonstrations. The practical sessions were invaluable, allowing us to practice various surgical procedures under expert guidance. The course organization and materials were top-notch, making it easy to follow along and refer back to the content. Overall, I feel much more confident in my animal surgery skills after taking this course and highly recommend it to anyone who is performing rodent microsurgeries. Thank you so much for this experience, I really appreciated it.